Abstract: Objective To investigate the correlation between different clinicopathological factors and the recurrence and metastasis of advanced adenocarcinoma of the esophagogastric junction after curative resection, and to analyze the effects of the factors on the prognosis of these patients.
Methods The clinical data of 385 patients with advanced adenocarcinoma of the esophagogastric junction who received curative resection at the Affiliated Hospital of Tianjin Medical University from January 2000 to January 2007 were retrospectively analyzed. There were 228 patients did not have tumor recurrence and metastasis (non recurrence and metastasis group) and 157 patients had tumor recurrence and metastasis (recurrence and metastasis group). Risk factors which might influence postoperative recurrence and metastasis were analyzed using univariate analysis (chi square test) and multivariate analysis (Logistic regression model). All patients were followed up via out patient examination or phone call. The survival curve was drawn by Kaplan Meier method, and the survival analysis was done by Log rank test. Results The median time for follow up was 36 months (range, 3 〖KG*9〗108 months). A total of 157 patients had postoperative tumor recurrence and metastasis, and the mean time of tumor recurrence was 17.9 months. The results of univariate analysis showed that tumor type, differentiation degree, invasion depth, number of positive and negative lymph nodes, TNM staging were risk factors for the postoperative recurrence and metastasis of adenocarcinoma of the esophagogastric junction after curative resection ( χ 2 =22.814, P <0.05).
Conclusions Tumor type, invasion depth, number of positive and negative lymph nodes are independent risk factors of postoperative recurrence and metastasis of adenocarcinoma of the esophagogastric junction, and the number of positive and negative lymph nodes are important for the prognosis of patients with adenocarcinoma of the esophagogastric junction.